Best Fabric to Make Scrubs

Scrub material varies depending on comfort and functionality, but some fabrics stand out for their exceptional qualities. The best options include:

What are the Top 7 Best Fabrics for Scrubs?

1. Cotton Blend

A mix of cotton and polyester provides breathability while ensuring durability. This fabric is soft to the touch and typically allows for easy movement. Cotton-poly blends are also less prone to wrinkling and shrinking than 100% cotton, making them ideal for healthcare environments that require frequent laundering.

2. Polyester

Known for its moisture-wicking properties, polyester keeps the wearer dry and comfortable, making it ideal for long shifts in demanding environments. According to Good On You, polyester also holds color well, which helps scrubs maintain a professional look over time.

3. Rayon

This lightweight fabric offers a luxurious feel and drapes beautifully. It's often blended with other materials to enhance softness and flexibility. Rayon is made from natural cellulose, but it's important to note that its production can vary in sustainability depending on the source.

4. Spandex/Elastane Blends

These fibers are often added (2–5%) to improve stretch and flexibility. Scrubs with elastane move more freely with the body, providing essential mobility for bending, lifting, or long hours on the floor. Elastane doesn't absorb moisture, so it’s often combined with breathable base fabrics for balance.

5. Tencel (Lyocell)

Derived from sustainably sourced wood pulp, Tencel is both soft and strong, offering breathability and moisture control. It also naturally resists odor and bacterial growth, making it an excellent eco-friendly option for medical professionals.

6. Performance Fabrics

Many modern scrub brands use proprietary blends specifically engineered for healthcare settings. These fabrics are typically wrinkle-resistant, quick-drying, and fade-resistant, reducing the need for ironing or replacement. Performance textiles are often certified by independent standards such as OEKO-TEX®, ensuring skin safety and quality

7. Antimicrobial Fabrics

Antimicrobial treatments are applied to some scrub fabrics to reduce the risk of bacteria growth. While not a substitute for proper hygiene, they offer an extra layer of protection. According to the CDC, antimicrobial clothing may support infection control protocols in healthcare facilities.

Conclusion

When choosing scrubs, it’s essential to consider not just comfort but also how well the fabric performs under pressure—both literally and figuratively. Whether you value sustainability, flexibility, or moisture control, selecting the right fabric can enhance your workday and contribute to better hygiene, durability, and overall confidence on the job.

For more information about fabric safety, sustainability, or performance standards, refer to resources like OEKO-TEX®, Textile Exchange, or the CDC.

Ready to learn more about how to choose comfortable scrubs? Check out our ultimate guide here.